The present manuscript describe simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous estimation of Dithranol and Salicylic Acid in combined dosage form. Absorbance ratio method uses the ratio of absorbances at two selected wavelengths, one which is an iso-absorptive point at 278 nm in methanol. The second wavelength used is 258 nm, which is the ʎ-max of Dithranol in methanol. The linearity was observed in the concentration range of 1-5 µg/ml for both Dithranol and Salicylic Acid. The method was successfully applied to pharmacopoeial dosage form because no interference from the excipients was found. The results of analysis have been validated statistically and by recovery studies.
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